Retatrutide | Research Grade Peptide
Full Compound Name: Retatrutide (LY3437943) Molecular Formula: C₂₂₄H₃₅₆N₅₈O₆₈S₂ (free base) Molecular Weight: ~4,963 Da (approximately 4.96 kDa) CAS Number: 2381089-83-2 Purity: ≥98% (HPLC) Appearance: Lyophilized white to off-white powder
Retatrutide (LY3437943) is a synthetic acylated peptide analogue functioning as a triagonist at the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR). It is structurally derived from a modified glucagon backbone and incorporates a C18 fatty diacid moiety facilitating albumin binding and extended half-life in vitro. This multi-receptor engagement profile distinguishes Retatrutide from dual incretin agonists and renders it a subject of considerable interest in metabolic signalling research.
The compound belongs to the incretin mimetic peptide class and has been investigated in peer-reviewed literature for its receptor pharmacodynamics, binding affinity characterization, and downstream intracellular signalling cascades involving cAMP-mediated pathways.
Amino Acid Sequence
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys(C18 fatty diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH₂
(Aib = α-aminoisobutyric acid; residue modifications confer protease resistance and receptor selectivity)
Physicochemical Properties
| Property | Value |
|---|---|
| Molecular Formula | C₂₂₄H₃₅₆N₅₈O₆₈S₂ |
| Molecular Weight | ~4,963 Da |
| Solubility | Soluble in aqueous buffer (pH 7.4); DMSO (limited) |
| Form | Lyophilized powder |
| Counter Ion | Acetate or TFA (lot-specific; see CoA) |
Storage Instructions
- Long-term storage: −20°C in a sealed, desiccated environment
- Working aliquots: May be stored at 4°C for up to 7 days once reconstituted; avoid repeated freeze-thaw cycles
- Light sensitivity: Protect from ultraviolet and ambient light at all times; store in original amber vial or wrapped in aluminium foil
- Reconstitution: For research applications, sterile aqueous buffer (e.g., PBS pH 7.4) or 0.1% acetic acid is recommended; consult relevant literature for concentration-specific solubility guidance
- Handling: Use standard laboratory PPE; handle under aseptic conditions appropriate to the research protocol
Documentation
Each vial is supplied with a Certificate of Analysis (CoA) confirming identity, purity (≥98% by HPLC), and mass confirmation by ESI-MS.
⚠ Compliance & Regulatory Statement
This product is intended exclusively for in vitro and laboratory research purposes by qualified scientific personnel. It has not been evaluated, approved, or authorized by Health Canada, the U.S. Food and Drug Administration, or any other regulatory authority for use in humans or animals. This product is not a drug, medicinal product, or dietary supplement, and is not approved for human or veterinary consumption, administration, or therapeutic use of any kind. No health, safety, or efficacy claims are made or implied. The purchaser assumes full responsibility for compliance with all applicable federal, provincial, and local regulations governing the acquisition, handling, storage, and use of research chemicals. For research use only.
