BPC-157 + TB-500 | 10 mg / 10 mg | Research Grade Peptide Blend
Compound 1 — BPC-157 Full Compound Name: Body Protection Compound-157; Pentadecapeptide BPC-157; PL-10 Molecular Formula: C₆₂H₉₈N₁₆O₂₂ Molecular Weight: 1,419.55 Da CAS Number: 137525-51-0
Compound 2 — TB-500 Full Compound Name: Thymosin Beta-4 Fragment (Ac-LKKTETQ); TB-500; Tβ4 Acetylated Analogue Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S Molecular Weight: 4,963.44 Da CAS Number: 885340-08-9 (Thymosin Beta-4 reference)
Purity: ≥98% per constituent (HPLC) Appearance: Lyophilized white to off-white powder Quantity: 20 mg per vial (10 mg BPC-157 : 10 mg TB-500)
Description
This vial contains a co-lyophilized research blend of two structurally and mechanistically distinct synthetic peptides — BPC-157 and TB-500 — formulated at equimolar mass ratio for investigational use in cell biology and pharmacology research contexts requiring concurrent access to both compounds.
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide of 15 amino acid residues derived as a partial sequence analogue of the human gastric juice protein BPC. The compound exhibits notable aqueous stability and resistance to enzymatic degradation across a broad pH range in vitro, and has been employed as a model substrate in preclinical research examining nitric oxide (NO) system interactions, VEGF receptor signalling, and FAK-paxillin pathway activity in cell culture systems.
TB-500 is a synthetic N-terminally acetylated heptapeptide corresponding to the conserved LKKTET actin-binding motif (residues 17–23) of the full-length human Thymosin Beta-4 (Tβ4) polypeptide. As the principal G-actin sequestering domain of Tβ4, this fragment has been extensively utilized in cytoskeletal biology research to investigate actin polymerization kinetics, filamentous actin (F-actin) dynamics, and endothelial cell migration signalling cascades in vitro.
The two peptides are supplied as a single co-lyophilized blend to facilitate streamlined reconstitution in research protocols requiring both compounds. Each constituent retains its independent physicochemical identity within the blended matrix and can be verified independently via lot-specific CoA documentation.
Amino Acid Sequences
BPC-157: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (15 residues; linear; free acid form)
TB-500: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH (7 residues; N-terminally acetylated)
Physicochemical Properties
| Property | BPC-157 | TB-500 |
|---|---|---|
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | 1,419.55 Da | 4,963.44 Da |
| Solubility | Water; 0.1% acetic acid | Water; PBS (pH 7.4) |
| N-Terminal Modification | None (free amine) | Acetylated (Ac-) |
| Counter Ion | Acetate or TFA (see CoA) | Acetate or TFA (see CoA) |
Blend Composition: 10 mg BPC-157 + 10 mg TB-500 per vial (20 mg total lyophilized mass)
Storage Instructions
- Long-term storage: −20°C in a sealed, desiccated environment
- Working aliquots: May be stored at 4°C for up to 7 days once reconstituted; avoid repeated freeze-thaw cycles
- Light sensitivity: Protect from ultraviolet and ambient light at all times; store in original amber vial or wrapped in aluminium foil
- Reconstitution: Reconstitute in sterile deionized water or bacteriostatic water; gentle agitation is recommended; avoid vortexing; PBS (pH 7.4) is suitable for aqueous working solutions
- Handling: Use standard laboratory PPE; handle under aseptic conditions appropriate to the research protocol
Documentation
Each vial is supplied with a Certificate of Analysis (CoA) confirming the identity and purity (≥98% by HPLC) of each constituent peptide independently, with mass confirmation of both compounds by ESI-MS.
⚠ Compliance & Regulatory Statement
This product is intended exclusively for in vitro and laboratory research purposes by qualified scientific personnel. It has not been evaluated, approved, or authorized by Health Canada, the U.S. Food and Drug Administration, or any other regulatory authority for use in humans or animals. This product is not a drug, medicinal product, or dietary supplement, and is not approved for human or veterinary consumption, administration, or therapeutic use of any kind. No health, safety, or efficacy claims are made or implied. The purchaser assumes full responsibility for compliance with all applicable federal, provincial, and local regulations governing the acquisition, handling, storage, and use of research chemicals. For research use only.
